1, yesterday morning, go to the hospital transfusion, transmission on the left g (levofloxacin injection) in less than a few minutes, his voice tight, hold back hair, until all the teeth are numb. The symptoms are similar to pipe a little zip lock. I wanted to teeth, so that rattan cane to me a bit slow the flow, regardless of use. I said to Heding Hong efficacy did not so quickly, right? then quickly mute my voice out, and vomiting. Two girlfriends emergency doctor to the dressing and rapidly injected with allergy.
2, the doctor said then save a minute later, my throat will be completely closed, must directly cut, intubation breathing. There is also a land approach to the animals injected with about dozens of the huge number of needle directly to the neck and tie a big hole. breathes breathing.
3, the speech difficulties, I get the usual low-key deep nonsense, just with open tears bark, and the innocent and helpless, pathetic, sort of a small two eyes, separated glasses, nostalgia, looking at the world. think of the money not spent finished, people do not love enough, the sadness of parting, with mixed feelings. < br> 4, hula family came to the hospital. Our family Daniu rushing tears. Erniu indifferent to our house (since she can never expect to eat great dragon (Wing) shrimp).
5, yesterday afternoon and evening, to drink cup of warm boiled water reached nearly to eat watermelon two, the mouth piece with a dozen VC buccal tablets. crazy sweating, urinating on the toilet an average of five minutes once. finally left grams (levofloxacin injection) is scheduled to be almost the same.
6, now no longer face pale, Yin-Tang no longer blue, his voice has been able to speak. Daniu said: Silent cute, now you're restored to the world's most annoying bitch. is certainly not an injection. can not resolve injection infusion.
2, not because hospitals everywhere when you are president of the iron sister, Director of Nursing you have no big problems go to the hospital to play. accounting for the mental hospital cheap no longer there. more not to lie and they want to talk to his girlfriend on an intravenous drip.
3, left millions of caution grams (Levofloxacin Hydrochloride Injection) and all easy to allergy medications. my daughter was allergic to penicillin are also shock . if you feel unwell, do not hesitate, do not observe an immediate pull fluid.
4, said her daughter went to the hospital to see me cry I think the way: my mom giant strong man, and never trouble people. certainly only for his family to die, son wants his parents away, but Mom did not know women want to study. So little friends to remind you learn every day, do not let my parents worry.
Here is what I left in the online search grams of allergy cases reflect:
of : pete2188 filing date :2006-7-3 23:53:37
girlfriend a few days ago with fever fever of 39 degrees, go to Shanghai Punan hospital emergency room doctor on duty for a blood test, then decided to give fluids, we remind penicillin allergy The doctor said that he cephalosporins? We asked cephalosporins penicillin allergy can play it? decided to play left-grams, 0.3g (5% glucose 500ml) * 3 days, things started from the left-grams. infusion also reclaim heat for two days, during accompanied by dizziness, palpitation, suffocation, cold sweat, excitement, headache, insomnia, nausea, skin rash (purpura, systemic showed migratory pain), consult a doctor, saying that there is a cooling process. to continue treatment. end of the day infusion, heat has not yet retired, also increased the diarrhea, the body was becoming more and more migratory severe pain, allergic purpura red dot increases. can be said that all the side effects of left grams have emerged. I really do not know the manufacturer and the hospital how the services for patients.
We hope that we note that levofloxacin with hydrochloric acid when the alert to avoid the physical suffering of more pain ..
: pete2188 Reply Date :2006 -7-323: 54:00
Here is another User's Friendly reminder: the left g (Levofloxacin Hydrochloride Injection)
Indications:
This product applies to the following sensitive bacteria in severe infections: 1. Respiratory infections: acute bronchitis, acute exacerbation of chronic bronchitis, diffuse bronchitis, bronchiectasis with infection, pneumonia, tonsillitis (peritonsillar abscess). 2. Urinary tract infections: pyelonephritis, complicated urinary tract infections 3.. reproductive system infections: acute prostatitis, acute inflammation epididymis, uterine infection, uterine annex inflammation, pelvic inflammatory disease (suspected anaerobic infections can be combined with metronidazole). 4. skin and soft tissue infections: infectious pus blister disease, cellulitis, lymphatic (node) inflammation, subcutaneous abscess, anal abscess. 5. gastro-intestinal infections: bacillary dysentery, infectious enteritis, salmonella enteritis, typhoid and paratyphoid. 6. sepsis, granulocyte cells decreased and immunocompromised patients with various infections. 7. Other infections: mastitis, trauma, burns and surgical wound infection, abdominal infection (combined with metronidazole if necessary), cholecystitis, cholangitis, bone and joint infections and ENT infections.
��Usage and Dosage��:
intravenous drip: Adult daily 0.4g, 2 times intravenous infusion. pathogen of severe infection and is less sensitive to the chemicals (such as Pseudomonas aeruginosa Aeromonas), maximum daily dose can be increased to 0.6g, intravenous infusion of 2 times.
grams for the left, to note that its side effects. Of course, all the drugs will have side effects.
from the north Medical Hospitals Allergy symptoms will not occur. However, to avoid the occurrence of allergic symptoms, requirements: the infusion time, the slow trickle. usual dose vials, the input of not less than one hours time.
this knowledge because of the recent their loved ones, lost in half an hour left over .24 grams or more hours there than that, in addition to all the allergy symptoms of vertigo: First, rapid heart rate, chest tightness, shortness of breath, nausea, headache, high fever does not retreat excited can not sleep, then whole body and face skin rash and erythema, it is painful
of: pete2188 Reply Date :2006-7-3 23:57:00
Chief Medical Network>> Magazine>> China Modern Clinical Medicine> net Zhou Hui 2006-2-23 21:39:03 Journal of Modern Clinical Medicine January 2006 Volume 4 No. 2
Keywords: Levofloxacin
Abstract In this paper, recent years on levofloxacin (LVFX) documentation of adverse reactions to summarize, the main side effects include gastrointestinal reactions, allergic reactions, and central nervous system reactions. prompted the clinical use of the drug when in the stricter control over their indications, take the right to use, and careful combination to avoid and reduce adverse reactions.
Key words levofloxacin; adverse reactions
levofloxacin (levofloxacin, LVFX) was first developed in 1994 by the Japanese successfully developed, it is the 3rd generation quinolone antibacterial drug is the racemic ofloxacin enantiomer, the antibacterial spectrum covering gram-positive bacteria, Gram-negative bacteria, anaerobic bacteria, atypical pathogens, and mycobacteria. In vitro antibacterial activity of oxygen 2 times the fluoride Sand Star, D-Body (R-OFLX), 8 ~ 128 times. oral bioavailability, tissue permeability, can be quickly distributed to various organizations, long half-life, 85% through urine excretion. extensive for respiratory, gastroenterology, gynecology, dermatology, surgery and other departments. In this paper, the past 5 years at home and abroad about the adverse effects of levofloxacin appears to summarize the literature data, are summarized below.
1 gastrointestinal reaction
Lv Libo [1] and reported in the treatment of tuberculosis with LVFX injection in 24 patients with varying degrees of side effects: gastrointestinal reactions including 10 cases (41.67%), dizziness, headache in 6 patients (25.00%), pruritus, rash in 5 patients (20.83%), fever, heart palpitations in 2 cases (8.33%), blood urea nitrogen increased 1 (4.17%). All of the above adverse symptoms disappeared after stopping.
2 induced ascites
Wu Xia [2] reported 1 patient was male, 23 years old, a university student. because of headache, sore throat, fever 2 days, on the evening of 21 June 2003 10:00 to treatment. Patients usually physical health, no history of drug allergy . doctors, giving LVFX 200 mg intravenous infusion of 1. 5:00 am the next day, patients with nausea, abdominal distension, abdominal pain, diarrhea, abdominal palpation can be heard, and shifting dullness. B ultrasound diagnosis: ascites (in volume). Disable LVFX. immediate 5% glucose injection 500ml + intravenous dexamethasone 15mg, furosemide 20mg intramuscular injection, intravenous infusion of 20% mannitol 250ml. 8:00 am on day 2, patients with these symptoms, review B- showed no abnormal echo abdominal .2004 Jan. 2, the patient re-infusion LVFX 200mg, once again the above symptoms, B ultrasound diagnosis of ascites. by using the same measures after treatment and gradually returned to normal after the drug is not used, then did not have the symptoms, so consider patients with ascites due to LVFX.
3 allergic reaction allergic drug eruption
3.1 Wu Wei Yan [3] reported one case of female patients suffering from acute purulent tonsillitis intravenous levofloxacin mesylate (Lee Fosun), skin rash during the infusion, the patient in the event of no notice after drug eruption, outdoor activities are more sun, skin rash was worse. of the opinion that the product has a phototoxic reaction (occurring rate of <1%), may result in increased symptoms.
3.2 anaphylactic shock
1 patients with 23-year-old female patient [4], the FDA due to acute gastroenteritis 100ml, dropping speed of 30 drops / min. medicine 5min after the dizziness, limb numbness, followed by symptoms of anaphylactic shock. quickly to anti-shock treatment, about 15min after the above symptoms gradually improved, blood pressure, pulse, respiration returned to normal consciousness turned clear.
3.3 speed hair and delayed type hypersensitivity
Yangming Na [5] reported LVFX induced anaphylactic shock in elderly patients in 2 cases, 1 male patients, aged 82, the patient again in 2 days intravenous infusion of hydrochloric acid LVFX 2min only about the first appears dizziness, sweating, fatigue, hold breath, accompanied by a transient disturbance of consciousness.
LVFX not only led to immediate hypersensitivity, has also led to delayed allergic reactions. Zhuangshu Ping [6] reported that in February 2001, in the sections of their total of 98 patients using the injection LVFX HCl, 5 patients had symptoms of delayed allergic reactions, usually 8 to 12 days treatment appears to have been discontinued and allergy treatment improved. were denied the application in the treatment of other cause during allergy medicine and food, so consider delayed allergic reactions caused by LVFX Department of hydrochloric acid.
3.4 Ashland - Hengnuo syndrome
Liang Pi-xia [7] reported 1 case of female patients, 62 years old, no history of drug allergy, for and excellent surge levels. The next morning there were large migratory joint swelling and pain the whole body, with skin congestion, limited mobility. from the elbow to the knee, wrist, ankle involvement in turn, first right after the left side. At the same time Ministry of right elbow, left knee, right leg and bilateral hip extensor surface of bleeding papules, sizes and irregular, non-itching. with paroxysmal abdominal pain, nausea and vomiting. to the hospital to joint pain of unknown origin, The above symptoms improved, were discharged after 10 days.
3.5 limbs, face, abdomen numbness
m extension from [8] reported 1 case of female patients, aged 28, due to intravenous infusion of upper respiratory tract infection Bupleurum injection, LVFX HCl injection (left grams), medication suddenly felt numbness in patients after 30min, and then the face, abdomen numb, his hands itching, difficult to tolerate, no rash appears. the withdrawal, to give 10% calcium gluconate injection solution, 5% glucose injection, itching stopped after about 10min, then the limbs, face, abdomen numbness have disappeared. The next day, still with the Bupleurum injection fever, and the other using tobramycin injection (properly Xin), until the patients recovered without any adverse reactions occur again. so that the occurrence of allergic reactions are caused by the hydrochloric acid injection LVFX.
of: pete2188 Reply Date :2006-7-4
3.6 off hand-foot skin Chip
Yin Lihua [9] reported 1 case of female patients, aged 70, due to secondary infection of bronchial asthma given aminophylline and LVFX (to Ericsson) 100mg, ivgtt, bid.3 days after the hand-foot skin itching, scaling, that disabled LVFX, 1 week after symptoms of hand-foot skin scaling improved again after 3 months in patients with application of LVFX and aminophylline, 1 day and hand-foot skin itching, scaling, disable LVFX 1 month later, the skin off Chip symptoms.
4 central nervous system reactions, and mental disorders
4.1
epilepsy beam winter months [10] reported one case of female patients, aged 17, in gonadal resection of epidural anesthesia for the prevention of infection, intravenous infusion of LVFX injection 0.4g / d. Enter 100ml 2 days later, the patient suddenly felt the whole body discomfort, facial muscle tension, twitching, eyes forced upward gaze, not closed, sweat more. But the mind clear, accurate answer , denied a history of epilepsy, and other related. examination: P 134 times / min, R 20 times / min, BP 18.0/12.0kPa (135/90mmHg). that disabled LVFX to diazepam (stable), were quiet after treatment sleep, the symptoms disappeared again after .2 h whole body discomfort, mild opisthotonus, again to the stability of symptoms and stable condition. after the switch to penicillin, no recurrence of similar reactions. authors suggest that LVFX inhibits g-aminobutyric acid Therefore, to induce epilepsy. The sudden appearance of patients in the infusion of muscle tension, twitching, eyes forced upward gaze, sweat more, may be caused by epilepsy LVFX. a history of epilepsy should be careful using this, without a history of epilepsy also should be noted.
4.2
Chen Zelian insomnia [11] reported 2 cases of female patients: 1 case of 39-year-old, the other 1 case of 32-year-old, respectively, because of cough, urinary tract infection oral LVFX (Cravit) 100mg , bid. before the one case 3 days after medication, after one case 7 days after medication were insomnia, excitement, could not sleep, and with continued symptoms of increased medication, 2 patients after treatment of insomnia symptoms disappear .2 excited patients were not taking other drugs during treatment, the authors believe that insomnia by the LVFX (Cravit) due.
4.3
Wang Dongyun Parkinson's disease [12] reported one case of male patients, aged 60, due to chronic bronchial inflammatory attack, taking LVFX (Beijing Erbitux new) 200mg, bid, with the amount of bromhexine regular service. after 2 days, dosage was reduced LVFX 100mg, bid. the first 3 days intractable hiccups, face expressionless, speech reduction and withdrawal. hiccups disappeared within 2 days after treatment, but have been slow to appear, writing difficulties, panic, unsteady gait and other symptoms, and gradually increase, resulting in standing firm, and fell 1. mental patients without neurological history, sane, no vomiting, normal vital signs, limb increased muscle tone, tendon reflexes, diminished or disappeared. The switch to a higher level Department of Neurology, a diagnosis of Parkinson's disease. The application of drugs such as trihexyphenidyl 1 week after treatment, the symptoms improved disappear. authors believe that the amount of patients with previous repeated conventional application of bromhexine no abnormal reaction, disable LVFX and anticholinergic drugs given shortly after the disappearance of the symptoms can be caused by Parkinson's disease that is LVFX.
4.4 Magic Cui Yu as
[13] reported one case of female patients, aged 76, under double-lung infection due to intravenous infusion of LVFX (to Ericsson) 0.1g, 2 times / d, see the disease in patients with medication the next day and shoot a lot of room ceiling mud flow, the infusion bottle is mud. conscious patients, the pathological negative for neurological consultation. medication 3 days after LVFX (to Ericsson) to ceftriaxone, and the remaining the same, dressing 3 days after the visual hallucinations disappeared.
4.5
Nan mental disorders [14] reported one case of female patients, aged 32, no spiritual past, neurological history, admitted to hospital because of incomplete intestinal obstruction, to decompression, intravenous injection LVFX, 2 days symptoms, 3 days ago suddenly visual hallucination auditory hallucination, visual inversion, image blur, unconscious laughing and crying, strip lying land. The investigation of liver and kidney function and electrolytes were normal, due to adverse reactions considered as LVFX. the withdrawal , 6h spirit returned to normal after the patient has no memory of history with .1 weeks after LVFX, patients and the above symptoms, immediately discontinued, relapse is not observed 4 days after discharge from hospital were followed up for six months, the spirit has always been normal.
5 adverse neuromuscular system neuromuscular syndrome
5.1
related Ming Wah [15] reported one case of female patients, aged 22, in the neck under general anesthesia, excision of lymphoma and 12 noon on the same day pm and 4 pm, two intravenous infusion of LVFX injection (Lee Fosun) 0.2g, 6 am the next day, the patient appeared stiff neck, limbs 3 times paroxysmal seizures, each lasting about 5min, followed by 30min interval and 20min, were conscious. consultation that the application of surgery droperidol (droperidol) induced extrapyramidal reaction after intramuscular injection of scopolamine given symptomatic relief to continue to give .11 Lee Fosun 0.2g, bid (twice the interval time of 1h), 2 pm, patients are again neck stiffness, limb convulsions 1, again resolved after intramuscular injection of scopolamine. Since then disable LVFX, no recurrence of similar symptoms, it can be identified adverse reactions due to LVFX. of that LVFX as quinolones, can cause central nervous system adverse reactions, and was positively correlated with the dose. 2 times the clinical dose of the short interval given continuously, dropping speed is also fast, caused by high blood concentration prone to cause adverse reactions. study confirmed that quinolones inhibit brain g-aminobutyric acid (GABA tyrosine) role, which led to a series of central nervous system symptoms, the degree of response was positively correlated with the dose, infusion time must not be less than 60min, twice infusion interval should be more than 1h.
5.2 rhabdomyolysis
Ho Mui [16] reported one case of male patients, 90 years old, upper respiratory tract infections due to oral administration of LVFX (Cravit) 0.1g, 3 times / d, next morning wake up feeling weak and fall, can not stand. pm admission, initially suspected: upper respiratory tract infection, drug allergy checks after the last confirmed by a variety of rhabdomyolysis with acute renal failure, consider LVFX cause. < br> 5.3 Achilles tendinitis
Sun Yongli [17] reported one case of male patients, aged 34, due to acute bronchitis intravenous infusion of LVFX (Sino-US joint venture in Suzhou of the Long March - Xinkai Pharmaceutical Co., Ltd.) 0.2g, bid, right foot pain medication 3 days later, did not dare touch the ground, orthopedic consultation: Achilles tendinitis. The disabled LVFX, bed rest, local heat, were discharged after 3 days. LVFX abroad have occurred related to reports of Achilles tendinitis. < br> 6 superinfection
Zhang Zheng [18] prospective study in 7 hospitals in Beijing to use all of LVFX injection drug users hospitalized patients .2661 cases of adverse reactions occurred in 105 cases of adverse reactions was 3.9% , where severe adverse reactions 4.8%, all double infection. LVFX irrational drug use accounted for 19.9%, focused on the elderly population over the age of 60, the main problem for the course too long or too short. unreasonable adverse drug reactions leading to direct cause of increased rates.
7 leukopenia
Wang Yan [19] reported one case of female patients, aged 32, hospital check WBC 4.4t109 / L, continuous epidural anesthesia in ovarian teratoma Excluding surgery, anti-inflammatory treatment 3 days after giving LVFX (to Ericsson) 0.2g, ivgtt, the first 4 days to give LVFX 0.2g, bid, review the WBC 2.8t109 / L, immediately stop LVFX, 3 days after the return to WBC 3.7 t109 / L, 10 days after the review return to WBC 9t109 / L, normal. The authors note that patients treated lactic LVFX anti-infective cause neutropenia, when the gradual recovery of white blood cells after treatment, indicating that the drug-related leukopenia and Clinical use of monitoring to the attention of LVFX blood, so as to avoid adverse consequences.
8
Li Wenhua hypoglycemic coma [20] reported 1 case of male patients, etc., 73 years old, 1 week due to diarrhea, fever 5 days, given LVFX 0.2g, ivgtt, bid and two octahedral smectite and other drugs, treatment for 6 days after diarrhea relief, for the consolidation effect, disable the other drugs, to continue to give LVFX, the first 10 days in patients with sudden confusion, check the trace peripheral blood glucose (FBG) 1.1mmoL / L, fasting blood glucose 0.77mmoL / L, a diagnosis of low blood sugar coma.
of: pete2188 Reply Date :2006-7-4 00:01:00
9 cardiovascular effects
9.1 QT interval prolongation
Samaha FF [21] reported one case of 88-year-old female patient after taking LVFX, QT interval prolongation 127ms, ventricular tachycardia occurred with atrial fibrillation. Therefore, the risk of serious cardiovascular disease, there is a history of arrhythmia, or electrolyte disorders in elderly patients with caution in patients with the drug. has been documented adverse reactions of quinolones, especially heart QT interval prolongation, so that the development of these drugs be restricted.
9.2 high blood pressure
LIU Ai [22] reported one case of male patients, 90 years old, because of bronchitis, pneumonia, lower right application of penicillin, cefazolin and other drug treatment is unknown, use LVFX (to Ericsson) intravenous (0.2g/100ml , qd), ampicillin / Shuba Tanner, cloth pseudo-ephedrine tablets, when the first group 1 LVFX 40min infusion, the patients with chills, shivering, chest, hands and feet get cold, T 37.9 ��, BP 253/14.7kPa ( 190/110mmHg), the disabled LVFX, given nifedipine, dexamethasone and other drugs, and to the physical cooling, 20min after the blood pressure dropped to BP 18.7/12.0kPa (140/90mmHg), continue to use ampicillin / Shuba Tanzania sodium drug treatment, no adverse reactions.
10 autoimmune hemolytic anemia
U.S. OH [23] reported 1 case of men such as white patients, 82 years old, due to the use of LVFX 10d cellulitis (500mg / d). after the result of severe jaundice, dizziness, fatigue, shortness of breath, dark urine and loss of vision to the emergency room, diagnosed with levofloxacin caused by autoimmune hemolytic anemia, received prednisone and the input concentration RBC PRBCs cured. The author believes that levofloxacin Although hemolytic anemia caused by an extremely rare but potentially lethal, should be immediately discontinued, and treatment for hemolytic anemia. for the use of fluoroquinolones hemolytic anemia patients, disabled levofloxacin.
11 other
LVFX as one of the national essential drugs are widely used in clinic. but because of the existence of these adverse reactions, use should pay attention to: (1) strictly dose regimen. LVFX at dose of 300 ~ 400mg, up to 600mg, more than the dose increased the incidence of side effects; high-dose or long-term applications are prone to cause liver damage [25,26]. it should pay attention to the clinical application of drug dose and treatment, try not to overdose medication, treatment should not be too long, especially for the elderly and the liver in patients with renal insufficiency the dosage should be strictly controlled and the treatment, when necessary, blood concentration monitoring, individualized drug administration. (2) seriously asked allergy history. LVFX side effects in patients with no history of allergy incidence 2.75%, a history of allergy was 4.47%, with significant differences (P <0.05) [24]. This product is not used for any kind of quinoline Well ketone who are allergic to antibiotics, because these drugs cross-reactivity between species [25,26]. Clinical whether patients should be asked in detail about the history of drug and food allergy, there is the history of penicillin allergy and allergic caution. (3) LVFX and combined with other drugs drug interactions may occur, therefore, permit conditions, concomitant medications should be minimized. (4) the elderly may be complicated by a variety of organs as disease, liver and kidney function decreased, compared prone to side effects, especially LVFX mainly from the kidney metabolism, reduction of required clinical treatment, if necessary, monitoring of renal function. In order to ensure drug safety, children should be disabled LVFX, 18 young people under the age of caution is appropriate, In addition, the clinical application require special attention to women, pregnant women, breastfeeding women should be banned [25,26]. (5) adverse reaction should be immediately discontinued, symptomatic treatment promptly.
of: pete2188 Reply Date :2006-7-4 00:03:00
��Reference��
1 Lvli Bo, Zhang Jing. levofloxacin in the treatment of tuberculosis caused by side effects clinical observation and treatment of 24 cases. Qiqihar Medical College, 2002,23 (3): 271.
2 Wu Xia. ascites caused by levofloxacin. Adverse Drug Reactions Journal, 2004,6 (6): 407.
3 Wu Wei Yan, Xie Ping. levofloxacin caused by severe allergic drug eruption. Journal of Adverse Drug Reactions, 1999, 1 (3): 186.
4 Long Gui-Ying, ZHU Wei-hua. anaphylactic shock caused by levofloxacin. Adverse Drug Reactions Journal, 2002,4 (2): 131.
5 Yangming Na, Sun Qing, Dong Feng. levofloxacin Anaphylactic shock caused by elderly patients in 2 cases. journal Adverse Drug Reactions, 2003,5 (1): 56.
6 Zhuang Shuping, Xingyue Ping, Xing Luying. Levofloxacin injection induced delayed allergic reaction in 5 cases. Medicine, 2002 , 21 (9) :581-581.
7 Liang Pi-xia, Yang Zhao Xu. Ashland Levofloxacin induced a Hengnuo syndrome in 1. Journal of Internal Medicine, 2000,39 (3): 209.
8 ��extension, the Sun Jian, Zhang Guangfang. Levofloxacin 1 case of anaphylaxis. Chinese Journal of New Drugs, 2002,11 (3) :253-253.
9 Yin Lihua. Levofloxacin Lactate Injection 1 case caused by hand-foot skin scaling. Chinese Journal of Clinical Pharmacy 2001,10 (4) :261-261.
10 beam winter months. levofloxacin caused by facial muscle twitch. Adverse Drug Reactions Journal, 2000,2 (4): 266.
11 Chen Zelian, management governance, Pan Xiaoou. levofloxacin cause insomnia in 2 cases, West China Medical Journal, 2003,18 (3): 402.
12 Wang Dongyun. oral levofloxacin induced Parkinson's syndrome in 1. Chinese Journal of Clinical Medicine, 2003,22 (7 ) :443-444.
13 Cui Yu, Lan Jian Hong. Intravenous mental abnormalities in 2 patients. Chinese Journal of New Drugs, 2003,12 (6) :428-428.
15 Guan Ming Hua, Song. levofloxacin caused by neck stiffness, limb convulsions. Adverse Drug Reactions Journal, 2001,3 ( 2): 125.
16 Ho Mui, places Yin Kong. rhabdomyolysis caused by levofloxacin case. Journal of Internal Medicine, 2001,40 (12): 880.
17 Sun Yongli, Zhao Jinrong. 1 Achilles tendinitis caused by levofloxacin cases. Clinical, 2004,32 (2): 44.
18 Zhang Zheng, Yan Jian-Cun, Zhan Siyan. Levofloxacin injection drug adverse reactions and forward-looking rational observation. Chinese Journal of Epidemiology, 2001,22 (6) :405-407.
19 Wang Yan, Chen Su husband, Xiong Xiaoyan, et al. Levofloxacin Lactate induced leukopenia. Adverse Drug Reactions Journal, 2002,4 (2): 125.
20 Li Wenhua, Li Jian, Wang Nan. Levofloxacin Mesylate 1 case of coma caused by low blood sugar. Chinese Journal of Clinical Pharmacy, 2002,11 (1): 40.
21 Samaha FF.QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin.Am J Med, 1999,107 (5) :528-529.
22 LIU Ai, Jian Liu. to Ericsson to serious hypertension in 1. Modern Applied Pharmacy, 2003,20 (6): 529.
23 Oh YR, Carr-Lopezi SM, Probasco JM, et al.Levofloxacin-induced autoimmune hemolytic anemia.Ann Pharmacother ,2003,37:1010-1013.
24 Liang Yan, Lu Yunlan. levofloxacin and adverse reactions relevant factors. China Medical Tribune ,2002-07-18.
25 National Pharmacopoeia Committee. Clinical Guide to the Chinese Pharmacopoeia (2000 edition). Beijing: Chemical Industry Press ,2001,702-707.
26 Chen Xinqian, gold has Yu, Tang light. New Pharmacy, 15th edition. Beijing: People Health Press ,2003,104-106.
Author: 655000 Yunnan Qujing, the First People's Hospital Pharmacy Qujing
(Editor: Tian)
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